Abcam, ab279374, Anti-BinCARD antibody [OTI4E10]

Size: 50µL
Mouse Monoclonal BinCARD antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CARD19.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI4E10,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CARD19.Q96LW7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The BinCARD protein also known as Bcl10 Interacting CARD Protein plays a significant mechanical role in cellular processes. It has a molecular mass of about 16 kDa and is known for its expression in various human tissues with high presence in the lymphoid tissues. BinCARD is a member of the caspase recruitment domain (CARD) family and engages in protein-protein interactions through this domain. Its primary function involves modulating signaling pathways that are essential for cell death and survival.
Biological function summary
In signaling processes BinCARD acts as a negative regulator of NF-kB activation. It associates with Bcl10 to influence signaling cascades that control immune responses and cell survival. BinCARD is not a part of any large multiprotein complex but rather operates through direct interactions with proteins like Bcl10. Its activity is important for the tight regulation of apoptotic signals ensuring balanced cellular outcomes in response to external stimuli.
Pathways
The protein BinCARD fits into several important biological pathways. One major pathway is apoptosis where BinCARD interacts with apoptotic proteins to modulate cell death. Additionally BinCARD is integral to immune response pathways particularly those involving NF-kB signaling often interacting with proteins such as MALT1 to influence downstream effects. These pathways highlight BinCARD's role in maintaining cellular equilibrium through control over important signaling networks.
BinCARD connects to immune-related conditions and certain cancers. Abnormalities in BinCARD function can lead to chronic inflammatory diseases where its regulatory effect on NF-kB is disrupted. Additionally alterations in BinCARD and related proteins like Bcl10 and MALT1 have links to lymphomas highlighting its involvement in oncogenic processes. Understanding these connections supports the exploration of BinCARD as a potential biomarker or therapeutic target in pathological states.