Abcam, ab279375, Anti-SH3BGR antibody [OTI1G7]

Size: 50µL
Mouse Monoclonal SH3BGR antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SH3BGR.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1G7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SH3BGR.P55822

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SH3BGR protein also known as SH3-domain binding glutamic acid-rich protein weighs around 11 kDa. This protein often shows expression in heart and skeletal muscle tissues. Mechanically SH3BGR interacts with proteins containing SH3 domains and contains a glutamic acid-rich region suggesting involvement in protein-protein interactions. Research shows that the protein localizes predominantly in the cytoplasm where it likely participates in cellular signaling events due to its structure.
Biological function summary
SH3BGR functions have a relation with signal transduction processes. It does not form part of any large recognized protein complex but its structural properties imply a role in binding activities affecting intracellular communication. SH3BGR might influence developmental and differentiation processes in tissues where it is expressed given the necessity for tightly regulated signaling pathways in these areas. Its precise biological activity is not fully elucidated but its interaction with SH3 domain proteins hints at a regulatory function.
Pathways
SH3BGR takes part in signaling cascades linked to the immune response and cell differentiation. It plays a role in the signal transduction pathways such as the MAPK pathway where interactions might include other SH3-domain proteins like Grb2. These pathways are important for transmitting extracellular signals to cellular responses. SH3BGR might also influence the actin cytoskeleton dynamics interacting with other proteins implicated in cytoskeletal organization impacting processes such as cell mobility and stability.
SH3BGR elements appear relevant in the context of muscular dystrophies and cardiac hypertrophy. These conditions can associate with faulty signaling in heart and muscle tissues where SH3BGR is expressed. In muscular dystrophies disruptions might involve altered interactions with dystrophin an important structural protein. In cardiac hypertrophy potential abnormal regulation in pathways involving SH3BGR and proteins like p38 MAPK could contribute to pathological changes in heart muscle cells influencing disease progression.