Abcam, ab279379, Anti-Upstream Binding Protein 1 antibody [OTI9G7]

Size: 50µL
Mouse Monoclonal Upstream Binding Protein 1 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human UBP1 aa 1-300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI9G7,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human UBP1 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9NZI7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Upstream Binding Protein 1 (UBP1) also known as HNF4α-stimulating factor (HSF) acts as a transcription factor involved in the regulation of gene expression. With a molecular weight of about 67 kDa UBP1 recognizes and binds to specific DNA sequences in the promoter regions of various genes mediating the transcription process. It is expressed in several tissues including the liver and heart where it plays a critical role in modulating the activity of target genes involved in metabolic and developmental pathways.
Biological function summary
UBP1 is important for facilitating RNA polymerase II-driven transcription by aiding in the formation of transcription complexes. It contributes to chromatin remodeling which promotes gene expression changes necessary for cellular functions. UBP1 interacts as part of larger multi-protein complexes recruiting other transcription factors and co-regulators to enhance or repress gene expression which directly impacts cellular growth and differentiation processes.
Pathways
UBP1 interacts within the Wnt signaling and PI3K-Akt pathways both of which are essential for regulating cell proliferation differentiation and survival. In the Wnt pathway UBP1 modulates the expression of genes required for normal cellular communication and fate determination. It also interacts with proteins such as β-catenin in the Wnt pathway and serves as a convergence point with other transcription factors influencing the expression of genes involved in cell cycle regulation and apoptosis.
UBP1 has a connection to metabolic syndromes like non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases. Dysregulation of UBP1 leads to abnormal expression of genes that contribute to lipid and glucose metabolism linking it closely to metabolic imbalances observed in NAFLD. Additionally altered interactions between UBP1 and transcription regulators like PPARα can intensify inflammatory responses and oxidative stress exacerbating cardiovascular disease conditions.