Abcam, ab279380, Anti-THAP8 antibody [OTI5D11]

Size: 50µL
Mouse Monoclonal THAP8 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human THAP8 aa 50 to C-terminus.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI5D11,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human THAP8 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NA92

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
THAP8 also known as Thanatos-associated protein 8 is a member of the THAP (Thanatos-Associated Protein) domain family. It is a protein with a mass of approximately 26 kDa. THAP8 functions as a sequence-specific DNA-binding protein where it identifies and binds to specific DNA sequences potentially influencing transcription processes. In terms of its expression THAP8 is particularly expressed in testis tissue suggesting a probable role in reproductive biological processes.
Biological function summary
The activities of THAP8 involve regulating gene expression possibly by acting as a transcriptional regulator. The THAP domain allows THAP8 to participate in DNA binding and protein-protein interactions. It is not widely recognized as part of a specific protein complex but its function often interacts with DNA and other associated proteins at a molecular level indicating an individual role in cellular regulation rather than within a large complex.
Pathways
THAP8 engages primarily in the regulation of transcription-related pathways. Its DNA-binding properties can modulate transcription factors and RNA polymerase interaction. This involvement suggests potential pathways related to gene expression in testicular development and function. Although not widely linked to specific proteins within these pathways its regulatory actions imply a collaboration with transcription machinery components in gene regulation processes.
THAP8 links specifically to reproductive health issues such as infertility. Due to its high expression in testicular tissue THAP8 could influence genes essential for sperm development and maturation. Defects or dysregulation of THAP8 might indirectly interact with proteins like CREM (cAMP-responsive element modulator) known for its role in spermatogenesis which could elucidate certain male infertility cases. Understanding the exact role and connections of THAP8 in these conditions requires further investigation.