Abcam, ab279391, Anti-NEUROD4 antibody [OTI1B7]

Size: 50µL
Mouse Monoclonal NEUROD4 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NEUROD4.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI1B7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human NEUROD4.Q9HD90

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from TCS., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NEUROD4 gene encodes a neuronal differentiation factor known as Neurogenic Differentiation 4 or bHLH (basic helix-loop-helix family member E33). This protein plays a critical role in neurogenesis and is closely related to the NeuroD family. NeuroD4 weighs approximately 42 kDa and expresses mainly in the developing central nervous system particularly in regions associated with sensory neuron development.
Biological function summary
Neurogenic Differentiation 4 functions as a transcription factor regulating gene expression during neural development. It participates in forming transcriptional complexes with other bHLH proteins facilitating neuronal differentiation and proliferation. By binding to E-box sequences in the DNA NEUROD4 influences the transcription of genes important for neuronal identity and precursory cell maturation.
Pathways
The NeuroD4 protein integrates into neurodevelopmental pathways including the Notch signaling and the Wnt signaling pathways. These pathways are pivotal for the control of cell fate decisions and proliferation in the nervous system. NeuroD4 interacts with other proteins within these pathways such as Notch intracellular domain proteins and TCF/LEF transcription factors further influencing the regulation of specific gene sets important for neural development.
Neurogenic Differentiation 4 associates with neurodevelopmental disorders like autism spectrum disorder and neuronal structure abnormalities such as retinal degenerations. Mutations or dysregulation of NEUROD4 can disrupt normal neural differentiation processes leading to these conditions. Connections to related proteins in these disorders include interactions with Onecut transcription factors relevant in developing retinal and other neural tissues.