Abcam, ab281584, Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001]

Size: 20µL / 100µL / 1mL
Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (ab281584) is a rabbit recombinant multiclonal antibody detecting Histone H3 in Western Blot, Flow Cytometry, IP, ICC/IF, Dot Blot, PepArr . Suitable for Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RM1001,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Dot, Flow Cyt (Intra), IP, PepArr, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Product Specifications
Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (ab281584) is a recombinant rabbit multiclonal antibody which is comprised of multiple monoclonal antibodies targeting different epitopes and recapitulating the performance of a polyclonal. Each component clone was developed by Abcam using patented rabbit monoclonal antibody technology.
Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (ab281584) is validated for use in Dot blot, Flow Cyt (Intra), ICC/IF, IP, PepArr and WB in human, mouse and rat samples.
Anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (ab281584) specifically detects Histone H3 (citrulline R2 + R8 + R17) (UniProt ID: P68431; Molecular weight: 15kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL).
Quality and Validation
Abcams high quality manufacturing and validation processes ensure anti-Histone H3 (citrulline R2 + R8 + R17) antibody [RM1001] (ab281584) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.
Related Products
Conjugation-ready, carrier free format available for antibody clone RM1001 -
ab283863
Target Information
This antibody is a key tool in cancer research, particularly in understanding histone citrullination's role in tumorigenesis, and is widely used in studies of gene expression, DNA repair, and autoimmune diseases like rheumatoid arthritis and lupus, involving protein arginine deiminases (PADs) and NETosis. Histone hypercitrullination is reported to play a role the progression of various cancers, including multiple myeloma, acute myeloid leukemia , lung cancer, and hepatocellular carcinoma.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle