Abcam, ab285366, Anti-TZP antibody [EPR25998-35]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal TZP antibody. Suitable for ICC/IF, IP, WB and reacts with Mouse, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25998-35,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IP, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target known as TZP also referred to as TAZ-binding protein functions mainly as an adaptor protein involved in various cellular processes. It integrates signals initiated by upstream signaling molecules serving as a bridge in cellular communication. The known molecular weight of TZP is approximately 49 kDa. Expression of TZP occurs widely but it is significantly present in tissues like the brain and liver indicating its broad biological relevance.
Biological function summary
The functioning role of TZP is important in cellular architecture and signal transduction engaging with the Hippo signaling pathway components. This protein is part of a multiprotein complex that stabilizes cytoskeletal structures and transduces external signals into cellular responses. It also interacts with transcription co-activators enhancing its role in regulating gene expression and maintaining cellular equilibrium.
Pathways
The balance and regulation of cell growth and apoptosis link TZP to critical pathways. The Hippo pathway in particular involves TZP actively by associating with YAP/TAZ proteins which are central regulators of organ size and tissue homeostasis. TZP’s interaction with these proteins highlights its contribution to controlling cellular proliferation and preventing tumorigenesis.
Several instances of cancer such as liver carcinoma have connections to abnormalities in TZP function. Dysregulation of TZP and its associated proteins like YAP and TAZ leads to altered cell differentiation and uncontrolled growth posing significant disease implications. Its involvement in breast cancer through pathways influencing hormonal response and cell cycle regulation further highlights its pathological significance.