Abcam, ab285376, Aftin-5

Size: 1mg / 5mg
MW 354.45 g/mol, Purity >98%. Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
Key facts
CAS number:1461717-05-4,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:354.45 g/mol,
Molecular formula:C19H26N6O,
Nature:Synthetic,
Solubility:Soluble in DMSOSoluble in ethanol,
Biological description:Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.,
Isomeric smiles:CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)C3=CC=CC=C3)=C2N=C1,
InChi:InChI=1S/C19H26N6O/c1-5-14(11-26)21-19-22-17(24(4)15-9-7-6-8-10-15)16-18(23-19)25(12-20-16)13(2)3/h6-10,12-14,26H,5,11H2,1-4H3,(H,21,22,23)/t14-/m1/s1,
InChiKey:HYFZLABHJHEEFS-CQSZACIVSA-N,
IUPAC Name:(2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called 2575 Aftin-5. 2575-1 is the same size as the 1 mg size of ab285376.
Protect from air and light.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes