Abcam, ab287032, STING Antagonist (H-151)

Size: 5mg
MW 279.34 Da, Purity >98%. H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Key facts
CAS number:941987-60-6,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:279.34 Da,
Molecular formula:C17H17N3O,
PubChem:7616033,
Nature:Synthetic,
Solubility:Soluble in DMSO to >75 mM,
Biochemical name:1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea,
Biological description:H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.,
Canonical smiles:CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32,
InChi:InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21),
InChiKey:UJZDIKVQFMCLBE-UHFFFAOYSA-N,
IUPAC Name:1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

Product details:
This product is manufactured by BioVision, an Abcam company and was previously called B2395 STING Antagonist, H-151. B2395-5 is the same size as the 5 mg size of ab287032.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C