Abcam, ab28759, Anti-ZDHHC13 antibody

Size: 100µg
Goat Polyclonal ZDHHC13 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ZDHHC13 aa 600 to C-terminus.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ZDHHC13 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8IUH4,
Specificity:This antibody is expected to recognise both reported isoforms (as represented by NP_061901 and NP_001001483).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This antibody was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 0.5% BSA, 0.5% Tris, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZDHHC13 also known as zinc finger DHHC-type containing 13 is a protein that performs a critical role in protein palmitoylation which is a lipid modification process that involves the addition of palmitate to other proteins. This modification process helps proteins with membrane targeting and function. ZDHHC13 weighs approximately 72 kDa and is primarily distributed in the brain and testes indicating its significant roles in these tissues. The protein's palmitoylation activity regulates protein trafficking stability and interactions making it essential for dynamic cellular processes.
Biological function summary
ZDHHC13 participates in cellular signaling and synaptic function. It can form part of a protein complex that modulates neuronal activity and development influencing neurotransmitter systems and synaptic plasticity. This protein plays an essential role in managing the distribution and function of various other proteins by facilitating their anchoring to cell membranes. Its function impacts excitatory neurotransmitter systems which are significant for maintaining normal cognitive processes.
Pathways
ZDHHC13 engages in pathways such as the Ras-MAPK signaling pathway and modulates signal transduction. These pathways influence cell differentiation proliferation and survival highlighting their importance in cellular activities. ZDHHC13 interacts closely with proteins like Ras and MAP2K affecting downstream signaling mechanisms that govern cell fate decisions. Through these pathways ZDHHC13's enzymatic activity can trigger or inhibit important signaling cascades.
ZDHHC13's dysfunction links to neurodegenerative diseases and cognitive disorders. Aberrations in its palmitoylation activity may lead to conditions like Huntington's disease and Alzheimer's disease. In these contexts ZDHHC13 interacts with proteins such as huntingtin and tau where altered palmitoylation impacts their stability and aggregation. Understanding this protein's role offers insights into potential therapeutic targets for treating neurological conditions.