Abcam, ab287700, Human PHLPP1 knockout A549 cell line

Size: 1000000Cells / vial
PHLPP1 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control available. To order both knockout and wild-type control cells: select 2 x 1000000Cells/vial. To order only knockout cells: select 1000000Cells/vial.
Key facts
Cell type:A549,
Species or organism:Human,
Tissue:Lung,
Form:LiquidSee storage information,
Knockout validation:Next Generation Sequencing,
Disease:Carcinoma

Product details:
Recommended control
: Human wild-type A549 cell line (ab288558). Please note a wild-type cell line is not automatically included with a knockout cell line order, if required please add recommended wild-type cell line at no additional cost using the code WILDTYPE-TMTK1.
We will provide viable cells that proliferate on revival.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our
limited use license
patent pages

Properties and Storage Information:
Gene name-PHLPP1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCOP also known as Secretory Carrier Membrane Protein plays an important role in the endocytic and exocytic transport processes. This protein weighing about 28 kDa is expressed in a variety of tissues including the brain lung and pancreas. It acts within cellular vesicles to mediate the secretion and uptake of essential molecules. These activities enable the cell to maintain material exchange which is important for normal cellular functions and communication.
Biological function summary
This protein takes part in intracellular transport helping in material distribution throughout the cell. SCOP associates with vesicular transport machinery components assisting in the precise navigation and fusion of vesicles. Through this association SCOP helps in the release of neurotransmitters and hormones affecting key cellular signaling processes. Its involvement in exocytosis renders it a part of the complex system overseeing cellular secretion.
Pathways
SCOP becomes integral in the regulation of vesicle trafficking. Its contributions are evident within two pathways: synaptic vesicle cycle and insulin secretion pathway. In conjunction with SNARE proteins SCOP aids in both docking and fusion during vesicle transport. These pathways permit smooth execution of neurotransmitter release and insulin secretion which are vital for neurological and metabolic processes respectively.
Dysregulation of SCOP associates with neurological disorders and metabolic diseases. Improper function of SCOP can impair neurotransmitter release leading to conditions like epilepsy. On the other hand aberrations in insulin secretion due to SCOP malfunction can contribute to diabetes mellitus. SCOP's interaction with other proteins like synaptotagmin during vesicle fusion highlights its importance across these diseases by impacting the vesicle lifecycle and associated metabolic outcomes.