Abcam, ab288156, Anti-Alpha-synuclein, isoform 98 and 112 antibody [EPR25115-65]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Alpha-synuclein antibody. Suitable for ICC/IF, WB, IHC-P, Flow Cyt (Intra) and reacts with Transfected cell line - Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25115-65,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Alpha-synuclein, isoform 98 and 112.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Alpha-synuclein also known as alpha-synuclein kDa or isoform ANX-112 is a protein with a molecular mass of approximately 14 kDa. It is mostly expressed in the brain especially in the presynaptic terminals of neurons. Structurally it is a small cytosolic protein that can form amyloid fibrils and is sensitive to chemical modifications. Alpha-synuclein plays a role in the regulation of neurotransmitter release and neuronal plasticity though its precise mechanisms remain an area of active investigation.
Biological function summary
Alpha-synuclein interacts with various membrane phospholipids and can form insoluble aggregates. These aggregates are part of complex structures known as Lewy bodies prominent in neurodegenerative conditions. This protein is implicated in synaptic vesicle trafficking maintaining synaptic function and neuronal adaptive responses. Alpha-synuclein may also modulate enzyme activities and participate in genomic stability reflecting its versatile cellular roles.
Pathways
Alpha-synuclein is involved in the dopamine synthesis pathway and membrane trafficking pathways. In these pathways it interacts with proteins like synapsin and SNAREs influencing vesicle fusion and neurotransmitter packaging. Its association with such pathways highlights its role in maintaining neuronal integrity and communication. Dysregulation of alpha-synuclein's normal function might disrupt these pathways resulting in pathological consequences.
Alpha-synuclein is most commonly linked to Parkinson's disease and Lewy body dementia. In these conditions abnormal accumulation and aggregation of alpha-synuclein into Lewy bodies occur. These aggregates impede cellular function and promote neuronal death. Additionally its relationship with other proteins like tau in the neurodegenerative disease context highlights its significant impact in multiple disorders associated with cellular aging and synaptic dysfunction.