Abcam, ab288296, Anti-ADA2 antibody [EPR25430-131]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal CECR1 antibody. Suitable for Flow Cyt (Intra), WB, IHC-P and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25430-131,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Adenosine deaminase 2 (ADA2) also known as ADA002 ADA-DUA or ADA2 is a protein involved in immune regulation and inflammation. ADA2 has a molecular mass of approximately 59 kDa. This enzyme expresses mainly in monocytes macrophages and dendritic cells. Its function involves the conversion of adenosine to inosine a critical step in purine metabolism that impacts cell signaling and immune responses.
Biological function summary
ADA2 plays an important role in modulating immune system activity and inflammation. Unlike its counterpart ADA1 ADA2 does not function as a monomer but as part of a larger protein complex. It participates in the maturation and differentiation of monocytes into macrophages and dendritic cells influencing both innate and adaptive immune responses. ADA2's functions suggest it has an effect on the vascular and immune system health.
Pathways
ADA2 holds a significant place in the adenosine signaling pathway where it regulates the balance between adenosine and inosine levels. This balance affects the extracellular signaling pathways that influence immune cell activity. ADA2 also interacts with other proteins in the inflammatory pathways notably influencing cytokine activity. Through these pathways it shows regulatory connections with proteins like CD39 and CD73 which also engage in purinergic signaling.
ADA2 plays an essential role in pathologies involving inflammation and immune dysregulation. Deficiency in ADA2 links to rare genetic disorders such as deficiency of ADA2 (DADA2) which presents with systemic inflammation vasculopathy and hematological abnormalities. In addition ADA2 shows involvement in conditions like rheumatoid arthritis where inflammation is a central feature. Its interaction with TNF-alpha and other pro-inflammatory cytokines positions ADA2 as a potential therapeutic target in inflammation-related diseases.