Abcam, ab289861, Anti-NPTXR + NPTX2 + NPTX1 antibody [EPR25684-9]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NP-I antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Recombinant fragment, Mouse, Rat, Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25684-9,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, WB, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NPTX1 NPTX2 and NPTXR collectively known as neuronal pentraxins are proteins that play a role in synaptic plasticity and remodeling. These proteins are characterized by their specific expression in the nervous system particularly in neurons. Neuronal pentraxin 1 (NPTX1) has a molecular mass of approximately 49 kDa while NPTX2 and NPTXR share a similar structural framework facilitating their interaction with each other and with synaptic partners. These proteins can localize on the cell surface and extracellular space where they participate in processes that maintain neural circuitry.
Biological function summary
Neuronal pentraxins participate in synaptic functions important for proper signal transmission within the brain. They act as a bridge between presynaptic and postsynaptic structures by binding to partners such as AMPA receptors promoting receptor clustering and facilitating synaptic connectivity. NPTX1 and NPTX2 can form a complex with NPTXR enhancing their role in synapse organization and contributing to neural network stability. These interactions support memory and learning by stabilizing the synaptic connections necessary for neural communication.
Pathways
Neuronal pentraxins engage multiple signaling cascades linked to synaptic function. They play a role within the glutamatergic signaling pathway where they influence synaptic plasticity through receptor interactions. Specifically these proteins associate with AMPA receptors contributing to receptor trafficking and modulation of synaptic strength. They also interact with proteins such as the neuronal pentraxin receptor forming an integral part of neural development and synapse maturation pathways.
Altered expression or function of neuronal pentraxins associates with neurodegenerative diseases like Alzheimer's and schizophrenia. These conditions involve disrupted synaptic processes where the imbalance of neuronal pentraxin activity contributes to pathological synapse loss. Changes in interactions with AMPA receptors affected by alterations in NPTX1 and NPTX2 may lead to cognitive deficits observed in these disorders. Additionally their activity connects to synaptic damage in neuroinflammatory conditions highlighting their relevance in maintaining neural health.