Abcam, ab289965, Anti-LZTR1 antibody [EPR25253-51]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal LZTR1 antibody. Suitable for ICC/IF, IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25253-51,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:Flow Cyt (Intra), IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LZTR1 also known as Leucine Zipper-Like Transcription Regulator 1 is a protein that plays a significant role in cellular processes. It has a mass of approximately 95 kDa and is expressed across various tissues including the brain heart and skeletal muscle. LZTR1 acts as part of the ubiquitin-proteasome system contributing to protein degradation by tagging specific proteins for ubiquitination. This process helps in maintaining cellular homeostasis by regulating protein levels within the cell.
Biological function summary
LZTR1 contributes to cellular regulation and signaling by being part of the Cullin-RING E3 ubiquitin ligase complex. This complex is important for targeting proteins for ubiquitination and subsequent degradation. Through this role LZTR1 helps control cell cycle progression and apoptosis. Its activity affects the stability and activity of proteins involved in these critical cellular processes ensuring efficient cellular function and response to environmental stimuli.
Pathways
LZTR1 is actively involved in the Ras signaling pathway particularly in the Ras-MAPK pathway. It interacts with proteins like Ras GTPase influencing pathway outputs by regulating turnover of specific Ras proteins. This interaction with the Ras-MAPK pathway is important for proper signaling that controls cell growth and differentiation. LZTR1 also intersects with the Hippo signaling pathway further impacting cellular proliferation and apoptosis.
LZTR1 is linked to conditions like Schwannomatosis and glioblastoma. Mutations or dysregulation of LZTR1 can disrupt normal cellular signaling and lead to uncontrolled proliferation associated with these diseases. In Schwannomatosis LZTR1 mutations are often found in conjunction with other proteins such as SMARCB1 which fuels tumorigenesis by impairing normal tumor suppressive functions. Understanding LZTR1's role in these disorders helps in developing therapeutic strategies targeting these pathways.