Abcam, ab290723, Anti-STEAP1 antibody [EPR26044-70]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal STEAP1 antibody. Suitable for WB, ICC/IF and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26044-70,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody recognizes overexpressed human STEAP1B isoform 1 and isoform 2 (#Q6NZ63). The antibody may also recognise endogenous STEAP1B isoforms.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
STEAP1 also known as Six Transmembrane Epithelial Antigen of the Prostate 1 is a plasma membrane protein with a molecular weight around 50 kDa. This protein is expressed primarily in prostate tissues but also in a variety of other epithelial tissues. It plays a mechanical role as a metalloreductase facilitating the reduction of metal ions such as iron and copper across the cell membrane. STEAP1 features a characteristic six transmembrane domain which is important for its activity and localization.
Biological function summary
STEAP1 impacts cellular processes connected to metal ion homeostasis and proliferation. By performing as a metalloreductase it modulates the redox state and availability of metal ions within cells. STEAP1 functions as part of a larger complex interacting with other transmembrane proteins in the regulation of ion transport and reduction reactions. These roles are significant in maintaining cellular metabolism and oxidative balance.
Pathways
STEAP1 is actively involved in pathways related to iron and copper metabolism. It links to the iron uptake and transport pathways ensuring proper cellular iron levels are maintained. STEAP1 also shares functional relationships with proteins such as ferritin which stores iron and transferrin which transports iron in the bloodstream. STEAP1 therefore plays an important part in connecting cellular metabolism to systemic metal homeostasis.
STEAP1 has notable associations with prostate cancer and Ewing's sarcoma. Elevated expression of STEAP1 often correlates with the progression of prostate cancer hinting at a potential role in tumor growth and survival. In Ewing's sarcoma STEAP1 engages in molecular mechanisms related to the disease's pathology. Interaction with proteins such as PCA3 a prostate cancer antigen underlines its involvement in carcinogenic processes and highlights its potential as a therapeutic target in oncology.