Abcam, ab300112, Anti-pan SCN antibody [EPR25134-4]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal pan SCN antibody EPR25134-4. Suitable for IP, WB, IHC-P, IHC-Fr and reacts with Mouse, Human, Rat, Transfected cell lysate - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25134-4,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:WB, IP, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target "pan SCN" also referred to as "IP SCN" and sometimes identified by "647" refers to a group encompassing several voltage-gated sodium channels commonly expressed in excitable tissues like the brain and skeletal muscles. These channels have different subunits that might have varying molecular weights but generally range around 220-260 kDa. They are essential for generating and propagating action potentials in neurons.
Biological function summary
Voltage-gated sodium channels aid in the rapid depolarization phase of the action potential in excitable cells. They open in response to membrane depolarization allowing the influx of sodium ions which is critical for the feedback cycle that continues the action potential. These channels typically comprise a core alpha subunit which forms the pore and optional accessory beta subunits that modulate functionality.
Pathways
These sodium channels integrate into critical signaling pathways like the ion homeostasis pathway and the sodium ion transport pathway. They interact with various proteins such as different isoforms of potassium channels and calcium channels to maintain the delicate balance of ionic gradients necessary for cell excitability and signaling integrity.
Mutations or dysfunctions in voltage-gated sodium channels relate strongly to conditions like epilepsy and certain skeletal muscle disorders. Epilepsy often associates with abnormal activity of the channels with related proteins such as GABA receptors and potassium channels also being implicated in the disorder's pathophysiology. Skeletal muscle disorders involve disruptions in ion channel functioning where calcium channels show significant interplay with these sodium channels in maintaining muscle contractions.