Abcam, ab300453, Anti-PIM1 antibody [EPR24447-39]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal PIM1 antibody. Suitable for WB, IP and reacts with Human, Mouse samples. Cited in 3 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24447-39,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PIM1 protein also known as Proto-oncogene serine/threonine-protein kinase Pim-1 is a serine/threonine kinase with a mass of approximately 44 kDa. PIM1 is expressed ubiquitously in the body but shows higher expression levels in hematopoietic tissues such as spleen thymus and bone marrow. Within the cell PIM1 predominantly locates to the cytoplasm but can also be found in the nucleus. The PIM1 protein contains conserved kinase domains which are essential for its catalytic activity.
Biological function summary
PIM1 protein plays an important role in cell survival proliferation and differentiation. It functions as a regulator within signal transduction pathways and although not forming part of a larger complex its kinase activity affects other proteins' phosphorylation status influencing various cellular processes. High levels of PIM1 expression are often associated with increased cellular proliferation and are involved in feedback loops enhancing cell survival.
Pathways
PIM1 protein contributes significantly to the JAK/STAT and PI3K/AKT signaling pathways which are important for the regulation of immune responses and cell growth. Within these pathways PIM1 interacts with other proteins such as STAT5 and AKT mediating signals that promote cell cycle progression and apoptosis inhibition. Its role is particularly important for the modulation of hematopoietic and immune functions where it facilitates cellular responses to external growth stimuli.
PIM1 protein is implicated in several cancers notably hematological malignancies like leukemia and lymphomas. The overexpression of PIM1 cooperates with oncogenes like MYC and BCL2 contributing to tumorigenesis by promoting uncontrolled cell proliferation and survival. Additionally PIM1 is under investigation for its role in cardiovascular diseases where it may impact cardiomyocyte survival and heart repair mechanisms. Targeting PIM1 and its associated pathways may offer therapeutic potentials in these conditions.