Abcam, ab300493, Anti-P2X3 antibody [EPR26568-3]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal P2X3 antibody. Suitable for WB, IHC-P, IHC-Fr, IP and reacts with Human, Mouse, Rat samples. Cited in 5 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26568-3,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IP, IHC-P, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
P2X3 also known as P2X purinoceptor 3 is a membrane-bound protein that functions as a ligand-gated ion channel. It has a molecular mass of approximately 40 kDa. P2X3 is expressed mainly in peripheral sensory neurons where it plays an important role in the detection of noxious stimuli by facilitating the entry of cations upon ATP binding.
Biological function summary
P2X3 contributes to the transmission of pain signals from the periphery to the central nervous system. This protein forms homotrimers or heterotrimers when combined with other P2X subunits like P2X2 allowing it to participate in various ion channel complexes. The activation of these channels leads to neuronal excitation and propagation of sensory signals.
Pathways
P2X3 operates within the purinergic signaling pathway specifically influencing neurogenic inflammation and pain perception. It closely interacts with the P2X2 subunit to modify neuronal responses to ATP. In the context of these pathways P2X3's ion channel activity is linked to the modulation of sensory neurotransmission impacting how stimuli are processed and perceived.
P2X3 is pertinent to conditions such as chronic pain and neuropathic pain. Its expression and function can affect the severity and persistence of these conditions. Notably P2X3 through its interaction with P2X2 is implicated in the development of abnormal pain responses. Understanding this relationship helps in the development of targeted therapies to alleviate pain by modulating P2X3 function.