Abcam, ab300519, Anti-Stargazin antibody [EPR25387-48]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Stargazin antibody. Suitable for IP, IHC-Fr, IHC-P, Dot, WB and reacts with Mouse, Human, Rat, Transfected cell line - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25387-48,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:Dot, WB, IHC-Fr, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Stargazin also known as γ-2 is a protein that modulates synaptic function by influencing AMPA receptor trafficking and their gating properties in neurons. It is a transmembrane protein with a mass of approximately 38 kDa. Stargazin is highly expressed in the brain predominantly in the cerebellum and hippocampus and is an important member of the transmembrane AMPA receptor regulatory protein (TARP) family. It directly interacts with AMPA receptors to regulate their surface expression and synaptic localization impacting synaptic plasticity and transmission in neurons.
Biological function summary
The protein known as Stargazin serves a pivotal role in the regulation of excitatory synaptic transmission. It forms part of a complex with AMPA receptors facilitating their proper trafficking to the postsynaptic membrane. Stargazin’s interaction with AMPA receptors is not just structural; it also modulates receptor activation and desensitization kinetics impacting neuronal communication. This modulation is essential for synaptic plasticity—a process underlying learning and memory.
Pathways
The interaction of Stargazin with AMPA receptors is central to the glutamatergic signaling pathway. This pathway is important for synaptic strength modulation and long-term potentiation. Stargazin also interacts with other TARP family proteins such as γ-3 γ-4 and γ-8 which further influences AMPA receptor trafficking across various brain regions. This association with different TARP proteins allows it to finely tune synaptic responses and modifies the receptor's contribution to neural signaling.
Stargazin plays a significant role in conditions like epilepsy and ataxia. Mutations or dysregulation in Stargazin disrupt AMPA receptor trafficking and synaptic signaling contributing to the abnormal neuronal activity observed in epilepsy. Moreover Stargazin is implicated in type 1 episodic ataxia due to its influence on cerebellar synaptic function which is vital for motor coordination. Stargazin’s interaction with other AMPAR auxiliary subunits can further exacerbate these disorders by altering receptor compositions and neuronal excitability.