Abcam, ab300571, Anti-HEPACAM antibody [EPR25296-150]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal HEPACAM antibody. Suitable for IHC-P, WB and reacts with Rat, Mouse, Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25296-150,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HEPACAM also known as "glialCAM" is a transmembrane glycoprotein that weighs approximately 55-65 kDa. It primarily appears in the glial cells of the central nervous system and plays a significant role in cell adhesion and communication. Researchers identified this protein in astrocytes oligodendrocytes and ependymal cells. It interacts with other cell adhesion molecules to mediate interactions between glial cells and contributes to maintaining the structural integrity of tissues.
Biological function summary
HEPACAM functions in the context of cell-cell adhesion and signal transduction mechanisms. This protein does not operate in isolation but rather forms part of larger protein complexes enhancing its role in cellular scaffolding and molecular signaling networks. The interaction with other cellular machinery supports processes like cell migration proliferation and differentiation which are critical for maintaining the homeostasis of neural tissues. Studies also highlight its role in modulating immune response and inflammatory processes within the nervous system.
Pathways
HEPACAM integrates into specific pathways involving cellular adhesion and signal transduction such as the PI3K/AKT signaling pathway. This pathway plays an important role in controlling cell growth and survival. HEPACAM's interaction with molecules like integrins and other cell adhesion proteins strengthens its function within this pathway. For instance integrins contribute to the regulation of the extracellular matrix composition affecting cellular movements and interactions vital for immune surveillance and responses in the nervous system.
Research associates HEPACAM with conditions like epilepsy and leukodystrophy. Alterations in HEPACAM expression or function can lead to improper cell adhesion disrupting normal tissue architecture and contributing to pathological states. Additionally there are links between HEPACAM and connexins proteins involved in forming gap junctions which further emphasizes its role in conditions characterized by impaired cellular communication. These associations highlight HEPACAM's involvement in maintaining neural stability and function within the central nervous system.