Abcam, ab300666, Anti-IMP5 antibody [1A1] (BSA and Azide free)

Size: 100µg / 1mg
Rat Recombinant Monoclonal IMP5 antibody. Carrier free. Suitable for WB and reacts with Human samples.
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:1A1,
Isotype:IgG2a,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Ion exchange chromatography Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IMP5 also known as Importin 5 is a protein that functions mechanically by facilitating the nuclear import of certain proteins and ribonucleoproteins. This nuclear transport process is critical for regulating gene expression and maintaining cellular homeostasis. The molecular mass of IMP5 is approximately 116 kDa. Expression of IMP5 occurs in various cell types with notably higher levels in rapidly dividing cells where active nuclear transport is essential for cell cycle progression.
Biological function summary
IMP5 plays a critical role in the nuclear-cytoplasmic transport system by forming a complex with other importins to shuttle cargo proteins across the nuclear envelope. This transport is necessary for the regulation of transcription factors and other proteins that impact cellular function. IMP5's involvement in the import complex highlights its importance in regulating components that influence cell growth and metabolism.
Pathways
IMP5 participates in the nuclear import pathway which is part of the broader cell signaling and regulation framework. It particularly interacts with Ran GTPase an important regulator of nucleocytoplasmic transport facilitating the import cycle of cargo complexes. Its action is also significant in the p53 signaling pathway where regulation of nuclear transport affects the activity and localization of p53 and associated proteins impacting cell cycle and apoptosis processes.
IMP5 has connections with cancer and neurodegenerative diseases. Its elevated expression links to various cancers where dysregulated nuclear import can impact tumor suppressor functions. Specifically it relates to the misregulation of p53 a protein frequently mutated in cancer. In neurodegenerative disorders altered nuclear transport involving IMP5 may disturb neuronal function and survival. Dysfunction in these pathways reveals the importance of IMP5 in both maintaining normal cellular function and its implication in disease states.