Abcam, ab302534, Anti-GluN3A+GluN3B antibody [EPR25287-45]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NR3A antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25287-45,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:The antibody exhibits low sensitivity when detecting rat samples. It is recommended to optimize experimental conditions by increasing the sample loading amount, using a lower antibody dilution ratio, and employing femtogram-level sensitivity substrates.

Product details:
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NR3A and NR3B also known as GluN3A and GluN3B are subunits of the NMDA receptor part of the ionotropic glutamate receptor family. They contain a molecular mass of approximately 129 kDa for NR3A and 130 kDa for NR3B. These subunits are expressed mainly in neurons within the central nervous system especially in the developing brain. Alongside the more common NR1 and NR2 subunits NR3 subunits play a unique regulatory role in NMDA receptor function and pharmacology.
Biological function summary
NR3A and NR3B modulate neuronal excitability by disrupting ion flow through the NMDA receptor channel acting as glycine-binding subunits. They integrate into NMDA receptor complexes with NR1 and NR2 subunits that form the receptor’s functional core. By altering calcium permeability and synaptic plasticity these subunits impact processes like learning and memory. The presence of NR3 subunits in the complex influences receptor properties reducing the excitatory response.
Pathways
NR3A and NR3B engage in the synaptic signaling and excitatory neurotransmission pathways which heavily depend on NMDA receptors. These pathways involve proteins such as NR1 and NR2 with which NR3 subunits interact to modulate synaptic transmission. The regulation of calcium influx and downstream signaling pathways including those impacting synaptic strength and plasticity is vital for various neuronal functions.
NR3A and NR3B influence neurodevelopmental and neurodegenerative conditions. Schizophrenia and Alzheimer's disease show links to dysregulated NMDA receptor activity with alterations in NR3 subunit expression playing a role. Research suggests that NR3-related modulation affects disease pathology and interactions with NR1 and NR2 subunits contribute to abnormal receptor function linked to these disorders. Studies focus on how targeting NR3 subunits may offer therapeutic avenues in such diseases.