Abcam, ab302562, Anti-TRIF (TICAM1) antibody [EPR24995-152]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal TRIF antibody. Suitable for WB, IP and reacts with Human samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR24995-152,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRIF also known as TIR-domain-containing adapter-inducing interferon-β is an adapter protein that plays an important role in the immune response. It has a molecular mass of about 85 kDa. TRIF is expressed in various tissues but most highly in immune cells like macrophages and dendritic cells. Mechanically TRIF acts within the signaling pathways by connecting Toll-like receptors (TLR) with downstream signaling molecules. It is essential for activating pathways that lead to the production of type I interferons and other cytokines.
Biological function summary
TRIF is part of the innate immune response mechanism. It functions as a central component in signal transduction processes especially in response to pathogen-associated molecular patterns (PAMPs). TRIF often forms complexes with other signaling proteins to activate transcription factors such as IRF3 and NF-kB which stimulate the expression of inflammatory cytokines and antiviral genes. This function allows the body to respond quickly to infections and initiate immune defenses.
Pathways
TRIF participates in important immune signaling pathways notably the TLR and interferon signaling pathways. In the TLR pathway TRIF interacts with proteins such as MyD88 and TRAF6 to propagate signals from TLR4 critical in detecting Gram-negative bacteria. Through its role in the interferon signaling pathway TRIF helps in the regulation of antiviral responses and is essential for the expression of interferon-stimulated genes that combat viral infections.
TRIF is associated with conditions involving abnormal immune responses such as autoimmune disorders and sepsis. Dysregulation of TRIF-mediated signaling can lead to excessive inflammation or defective immune responses contributing to disease pathogenesis. For example an overactive TRIF pathway may lead to increased susceptibility to sepsis due to augmented inflammatory cytokine production. TRIF also connects with proteins like IRF3 and NF-kB which are often implicated in autoimmune conditions due to their roles in persistent inflammation and immune cell activation.