Abcam, ab302718, Anti-AXL (phospho Y702) + MERTK (phospho Y753) + TYRO3 (phospho Y685) antibody [EPR26140-66]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Axl phospho Y702 antibody. Suitable for WB, IP, Dot and reacts with Human, Transfected cell lysate - Human, Synthetic peptide samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26140-66,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody cross-reacts with phosphorylated MERTK Y753 and TYRO3 Y685 based on dot blot data.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Axl MERTK and TYRO3 are receptor tyrosine kinases collectively known as TAM receptors. These proteins play important roles in cell signaling with Axl weighing around 98 kDa MERTK approximately 110 kDa and TYRO3 approximately 93 kDa. They are expressed in various tissues including the immune system the nervous system and reproductive organs. TAM receptors depend on ligands like Gas6 and Protein S to carry out their signaling mechanisms which are essential for their function.
Biological function summary
Axl MERTK and TYRO3 contribute to diverse cellular processes such as cell survival proliferation and phagocytosis. They form complexes with their ligands triggering downstream signaling pathways that regulate these vital processes. These receptors also maintain homeostasis in various systems by regulating the clearance of apoptotic cells and controlling immune response. Their signaling pathway often involves phosphorylation events that transmit signals from the extracellular environment into the cell.
Pathways
These receptors mainly participate in the PI3K/AKT and MAPK pathways acting as key modulators in cell growth and immune response. TAM receptors interact with molecules like PI3K an important mediator in the AKT pathway facilitating cellular processes like metabolism growth and survival. Their interactions support critical feedback loops that balance cellular functions and immune system adaptability.
Dysregulation of Axl MERTK and TYRO3 associates with cancer and autoimmune diseases. Overexpression or underexpression of these receptors can lead to tumor progression or inadequate immune response respectively. In cancer overactivated Axl often partners with EGFR or MET leading to enhanced proliferation and metastasis of cancerous cells. In autoimmune disorders such as systemic lupus erythematosus MERTK dysregulation can result in improper clearance of apoptotic cells contributing to persistent inflammation and autoantibody production.