Abcam, ab303506, Anti-GJC2 antibody [EPR26419-75]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Cx47 antibody. Suitable for IHC-P, IHC-Fr and reacts with Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26419-75,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GJC2 also known as Gap Junction Protein Gamma 2 or Connexin 47 (Cx47) acts in cell-to-cell communication through the formation of gap junction channels. This protein has a mass of about 47 kDa. It expresses largely in oligodendrocytes within the central nervous system as well as in Schwann cells in the peripheral nervous system. These junctions allow the transfer of ions and small molecules facilitating coordinated responses among cells important for nervous system function.
Biological function summary
GJC2 facilitates the transport of signaling molecules between neural cells. It integrates into gap junction complexes essential for maintaining the myelin structure in nerve cells providing proper electrical insulation. This protein's activity impacts the conduction velocity of nerve impulses. Its function in maintaining neural signaling underlines its key role in supporting the complex neural network facilitating proper cellular interactions and communication.
Pathways
GJC2 is critical in the neural signaling pathways related to myelin maintenance and gap junction organization. It associates closely with other connexins such as Connexin 32 (Cx32) within these pathways. The interaction among different connexins orchestrates cell signaling contributing to the homeostasis and electrical conductance in neural circuits essential for normal nervous system operations.
GJC2 mutations link to neurological conditions such as Pelizaeus-Merzbacher-like disease (PMLD) and Spastic Paraplegia type 44. Each of these disorders involves dysfunctions in myelin formation and maintenance leading to spasticity and other motor deficits. GJC2-related diseases often correlate with malfunctions or compensatory changes in other connexin proteins which further contributes to clinical variability and progression of these myelin disorders.