Abcam, ab305613, APC Anti-PHYHD1 antibody [EPR13313(B)]

Size: 100µL
Rabbit Recombinant Monoclonal PHYHD1 antibody - conjugated to APC.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR13313(B),
Isotype:IgG,
Conjugation:APC,
Excitation/Emission:Ex: 650nm, Em: 660nm,
Carrier free:No,
Applications:Target Binding Affinity, Antibody LabellingSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
conjugated primary antibody
is "made to order" and it is released using a quantitative quality control method that ensures binding affinity and labelling efficiency of the conjugate. Via leveraging the power of the
Lightning-Link® conjugation technology
, Abcam will deliver highly consistent recombinant conjugates in <2 weeks, giving you access to an ever growing portfolio of antibody-label combinations.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PHYHD1 protein also known as Phytanoyl-CoA Dioxygenase Domain Containing 1 functions as an enzyme involved in metabolic processes. It carries out oxidation reactions specifically hydroxylation on specific substrate molecules. PHYHD1 has a molecular mass of approximately 44 kDa making it a moderate-sized protein. Expressed in various tissues including the liver and kidneys PHYHD1 plays a significant role in managing metabolic activity within these regions contributing to cellular homeostasis and overall metabolic health.
Biological function summary
PHYHD1 participates in cellular metabolism by catalyzing reactions that modify fatty acids. This protein is involved in the breakdown of phytanic acid a complex fatty acid. In these reactions PHYHD1 may function independently or as part of larger protein complexes facilitating intricate steps that convert fatty acids into more usable forms. This process represents a significant part of lipid metabolism illustrating PHYHD1's role in maintaining the balance of lipid levels and energy within the cell.
Pathways
Researchers identified PHYHD1 in pathways related to fatty acid metabolism and chain elongation. In the context of the peroxisomal alpha-oxidation pathway PHYHD1 interacts with important proteins such as Peroxin and Phytanoyl-CoA alpha-hydroxylase which together assist in processing certain fatty acids. Additionally PHYHD1 links to other metabolic pathways involving oxidation reactions highlighting its central role in modulating lipid and energy metabolism.
Studies associate PHYHD1 with conditions such as Refsum Disease and disorders of fatty acid metabolism. Refsum Disease a genetic disorder involving the accumulation of phytanic acid sees a loss or reduction in PHYHD1 activity leading to severe symptoms. Through these associations PHYHD1 interacts with proteins like the phytanoyl-CoA hydroxylase enzyme exemplifying its critical role in the breakdown of fatty acids and linking its activity directly to disease state development and progression.