Abcam, ab306596, Anti-TRPC5 antibody [N67-15] - BSA and Azide Free

Size: 100µg / 1mg
Mouse Recombinant Monoclonal TRPC5 antibody. Carrier free. Suitable for IHC-P and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:N67-15,
Isotype:IgG2b,
Carrier free:Yes,
Reacts with:Human, Mouse, Rat,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab306596 ia a carrier free version of
ab306595
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TRPC5 also known as Transient Receptor Potential Canonical 5 functions as a calcium-permeable cation channel. This protein possesses a molecular mass of approximately 105 kDa. TRPC5 is expressed widely with high presence in neural and cardiac tissues. Researchers often investigate its role due to its integral function in calcium ion transport and involvement in neurological activities.
Biological function summary
TRPC5 plays a significant role in the cellular response to stimulating signals. It forms a part of the larger TRPC protein family complex facilitating the entry of calcium ions which are critical for various cellular processes. Activation of TRPC5 influences functions such as synaptic plasticity and neuroprotection. These roles demonstrate the importance of TRPC5 in cellular signaling and homeostasis within the body's systems.
Pathways
TRPC5 integrates into signaling networks like the phosphoinositide pathway. It interacts with proteins such as PKC and DAG which regulate its activity in response to extracellular signals. This interaction bridges TRPC5 to intracellular messaging pathways that mediate cellular growth differentiation and development.
TRPC5 is associated with conditions such as anxiety and cardiovascular diseases. In anxiety abnormal TRPC5 activity alters neuronal transmission processes. Connections between TRPC5 and proteins such as BDNF demonstrate its influence on mood regulation. In cardiovascular diseases altered TRPC5 expression affects blood pressure regulation and vascular function emphasizing its role in maintaining cardiovascular health.