Abcam, ab307201, Anti-Ifi204 antibody [EPR25256-211]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Ifi204 antibody. Suitable for Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, WB and reacts with Mouse samples. Cited in 2 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR25256-211,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-Fr, Flow Cyt (Intra), IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ifi204 also known as Interferon-activated gene 204 is a protein of the mouse involved in the immune response. It has a molecular mass of approximately 74 kilodaltons. This protein is expressed mainly in activated macrophages and neutrophils and contributes to the innate immune mechanism. It detects cytosolic DNA and activates the STING pathway to induce type I interferon production. It contains a HIN-200 domain that helps in recognizing specific DNA sequences.
Biological function summary
Interferon-activated gene 204 plays a role in the host defense mechanism. It functions as part of the cellular response to viral infections and potentially some bacterial infections. The protein is part of a larger complex involved in DNA sensing and it activates immune signaling pathways upon detecting foreign DNA. It interacts with components of the inflammasome participating in activating inflammatory responses necessary for pathogen clearance.
Pathways
Interferon-activated gene 204 participates in the cGAS-STING DNA sensing pathway. This pathway is essential for the production of type I interferons as a defense against viruses. The protein associates with cGAS and STING key players in the recognition of cytosolic DNA. Its role in this pathway highlights its importance in the body's first line of defense closely linking it to the activation of downstream signaling that involves IRF3 and NF-kB.
Altered expression or function of Interferon-activated gene 204 has connections with autoimmunity and inflammatory diseases. Its dysregulation may lead to excessive inflammation contributing to conditions like systemic lupus erythematosus. In this context it interacts with proteins such as AIM2 which is part of the inflammasome complex involved in autoimmune inflammation. Understanding its precise role in these diseases could potentially lead to new therapeutic strategies for managing autoimmune disorders.