Abcam, ab307348, Recombinant Human CCL14 Protein

Size: 10µg / 50µg / 100µg
Recombinant Human CCL14 Protein is a Human Full Length protein, in the 22 to 93 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, Mass Spec.
Key facts
Purity:>95% HPLC,
Endotoxin level:<0.005 EU/µg,
Expression system:HEK 293 cells,
Tags:Tag free,
Applications:HPLC, Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q16627,
Animal free:Yes,
Carrier free:No,
Species:Human,
Reconstitution:Reconstitute in PBS,
Storage buffer:pH: 7.4Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CCL14 also known as HCC-1 or HCC-3 is a small cytokine belonging to the CC chemokine family. It has a molecular weight of approximately 8 kDa. The protein is found in a variety of tissues where it is secreted by immune cells fibroblasts and endothelial cells. CCL14 interacts with chemokine receptors to mediate cell signaling and can be detected at the interface of inflammatory responses. Its expression can be modulated during different immune responses.
Biological function summary
The CCL14 protein acts as a chemoattractant for specific types of white blood cells including monocytes and lymphocytes which are critical in mounting immune responses. It does not function as a part of a larger complex but operates independently to influence immune cell trafficking. CCL14 is involved in modulating inflammatory reactions by recruiting immune cells to sites of tissue damage or infection. It helps orchestrate a coordinated immune response by activating target cells through its receptor binding.
Pathways
CCL14 plays important roles within the immune response and inflammation pathways. It contributes to the chemokine signaling pathway facilitating the migration and activation of leukocytes. Another significant pathway involving CCL14 is the MAPK signaling pathway which it influences through interactions with other signaling molecules such as CCL3 and CCL5. These relationships highlight CCL14's roles in both promoting and controlling immune responses.
CCL14 is linked to various inflammatory and immune-related diseases. It shows a strong association with chronic inflammation disorders such as rheumatoid arthritis where it contributes to tissue infiltration by immune cells. CCL14 also plays a role in atherosclerosis where it can influence the recruitment of macrophages that contribute to plaque formation. Through these conditions CCL14 interacts with other proteins involved in these pathologies including CCL2 and CXCL8 which further modulate inflammatory processes.