Abcam, ab307511, Anti-Munc13-1 antibody [EPR27022-47]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Munc13-1 antibody. Suitable for IP, Flow Cyt (Intra), IHC-Fr, IHC-P, WB and reacts with Rat, Mouse, Transfected cell lysate - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27022-47,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, IP, IHC-Fr, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Munc13-1 also known as UNC13A plays an important role in synaptic vesicle priming facilitating neurotransmitter release at synapses. This protein weighs around 200 kDa and is found mostly in presynaptic neurons. It interacts with the SNARE complex to mediate vesicle fusion ensuring efficient signal transmission across synapses. High expression levels are noted in the brain especially in regions involved in neurotransmission processes.
Biological function summary
Munc13-1 acts as a significant component of the presynaptic active zone. It interacts with proteins like syntaxin-1 to regulate vesicle docking and release. Munc13-1 forms part of larger protein complexes including RIM and Munc18 that regulate synaptic transmission. Within the complex it directly influences the readiness of synaptic vesicles thereby setting the stage for precise signaling in the nervous system.
Pathways
The protein Munc13-1 plays a critical role in synaptic signaling pathways like the neurotransmitter release pathway. It is closely linked with other proteins such as Munc18 and syntaxin in the SNARE complex which are essential for membrane fusion and neurotransmitter release. In the pathway Munc13-1 helps transform physical stimuli into electrochemical signals integrating into networks essential for neuronal communication.
The function of Munc13-1 impacts conditions such as autism spectrum disorders and schizophrenia. Its dysfunction or altered expression can disrupt synaptic communication contributing to these neuropsychiatric conditions. Munc13-1 has connections with proteins like RIM1 and syntaxin which are also involved in synaptic vesicle regulation and have known links to these disorders thereby highlighting its importance in maintaining neurological health.