Abcam, ab307668, Anti-NLRX1 antibody [EPR27216-40]

Size: 20µL / 100µL / 1mL
Knockout Tested Rabbit Recombinant Monoclonal NLRX1 antibody. Suitable for WB, IP and reacts with Human, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27216-40,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NLRX1 also known as NOD-like receptor X1 is a protein that plays a role in the regulation of immune responses and mitochondrial function. It has a molecular mass of approximately 110 kDa. NLRX1 is widely expressed in various tissues but shows higher levels in immune-related organs such as the spleen and lymph nodes. This protein is part of the NOD-like receptor family known for sensing intracellular signals and initiating immune responses.
Biological function summary
NLRX1 regulates immune functions by modulating inflammatory responses and innate immunity. It interacts with other cellular components to form complexes that impact the production of reactive oxygen species and influence mitochondrial dynamics. NLRX1 promotes mitochondrial homeostasis and cellular metabolism acting as a negative regulator of the inflammatory pathway. This protein also participates in antiviral responses by influencing signaling pathways upon detection of viral infections.
Pathways
NLRX1 plays critical roles within the NF-kB signaling and mitochondrial response pathways. It interacts with NF-kB-related proteins affecting the transcription of pro-inflammatory genes. Additionally NLRX1 connects with mitochondrial antiviral signaling proteins impacting the cell's ability to respond to viral agents. These interplays illustrate NLRX1's involvement in maintaining cellular balance in response to stress or infection.
Multiple studies link NLRX1 to conditions such as inflammatory bowel disease and viral infections like influenza. Its regulatory role in NF-kB and mitochondrial pathways connects NLRX1 to other proteins like MAVS and TRAF6 influencing the severity and outcome of these diseases. Altered NLRX1 function can disrupt immune regulation and promote chronic inflammation highlighting its importance in disease pathogenesis and potential as a therapeutic target.