Abcam, ab307723, Anti-SCXA antibody [EPR26997-33] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal SCXA antibody. Carrier free. Suitable for IHC-P and reacts with Rat, Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26997-33,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Mouse,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCXA also known as Scleraxis A is a transcription factor with a molecular mass of approximately 23 kDa. This protein plays a significant mechanical role in gene expression regulation particularly in connective tissues where it binds to specific DNA sequences. SCXA expression occurs in tendons ligaments and other fibrous tissues where it serves an essential function in development and homeostasis.
Biological function summary
The Scleraxis A transcription factor regulates the differentiation of progenitor cells into tenocytes the cells that form tendons. SCXA operates within a transcriptional complex that directs the expression of genes necessary for tendon extracellular matrix synthesis and organization. The regulation by SCXA ensures the structural integrity and function of tendons and connective tissues critical for movement and force transmission.
Pathways
SCXA participates in key developmental signaling processes including the TGF-beta signaling pathway and the Notch signaling pathway. These pathways influence various biological processes related to cellular differentiation and tissue development. SCXA interacts with other proteins such as Mohawk homeobox (MKX) which also functions in tendon development modulating the cellular responses through these pathways to impact the differentiation and maturation of connective tissue cells.
Aberrant SCXA expression or function links to tendon-related pathologies and fibrotic conditions. Research shows potential connections between SCXA and conditions like tendinopathy characterized by tendon degeneration and impaired healing. SCXA also interacts with proteins such as scleraxis B (SCXB) in the pathological context where disruptions in their activity may lead to changes in tendon structure and mechanics impacting tissue response to stress and injury.