Abcam, ab307893, Anti-RED1 + RED2 antibody [EPR26577-102]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal RED2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Transfected cell lysate - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26577-102,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RED1 and RED2 also known as RNA editing proteins are involved in the post-transcriptional modification of RNA molecules. RED1 has a molecular mass of approximately 60 kDa while RED2 weighs around 62 kDa. Both proteins are expressed in various tissues notably in the brain and liver where they function in RNA editing processes. These proteins participate actively in the editing of adenosine to inosine within RNA a critical step in processing RNA molecules for proper function.
Biological function summary
RED1 and RED2 play key roles in the regulation of gene expression by influencing the maturation and stability of RNA transcripts. Both proteins are integral components of the RNA editing complex working with other editing enzymes to make precise modifications. Through their activity they affect the function and diversity of proteins encoded by the modified RNA impacting cellular mRNA landscapes and influencing coding potential.
Pathways
RED1 and RED2 are significant contributors within the RNA-related regulatory pathways. Their editing activities are important in the RNA editing pathway impacting neuronal signaling and immune response pathways. These proteins interact with ADAR enzymes which help facilitate the conversion of adenosine to inosine in double-stranded RNA regions ensuring correct RNA sequence processing and function.
RED1 and RED2 have associations with neurodegenerative diseases and certain cancers. Aberrant RNA editing patterns involving these proteins are linked to Alzheimer's disease where disrupted RNA splicing and regulation occur. Furthermore cancerous growths often show altered expression of RED1 and RED2 connecting them to dysregulated cellular proliferation. These proteins interact with other key regulatory proteins like ADAR1 which also influences similar pathological pathways in these conditions.