Abcam, ab308072, Anti-HIV1 p55 + p24 antibody [EPR27327-79]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal GAG antibody. Suitable for WB, IHC-P, ICC/IF, Flow Cyt (Intra), I-ELISA and reacts with Recombinant fragment - Human immunodeficiency virus, Transfected cell lysate - Human immunodeficiency virus, Transfected cell line - Human immunodeficiency virus samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27327-79,
Isotype:IgG,
Carrier free:No,
Reacts with:Human immunodeficiency virus,
Applications:IHC-P, I-ELISA, ICC/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The HIV1 p55 + p24 refers to key proteins derived from the Gag polyprotein of HIV-1 a retrovirus causing AIDS. The Gag polyprotein is about 55 kilodaltons (kDa) and undergoes proteolytic cleavage to produce several structural proteins including p24. P24 has an approximate mass of 24 kDa. It forms the viral capsid which encases the viral RNA genome. These proteins are expressed during viral assembly in infected host cells important for the formation of virus-like particles. Western blot assays frequently utilize p24 due to its stable and abundant presence in viral particles.
Biological function summary
HIV1 proteins p55 and p24 play essential roles in viral replication and particle assembly. The p55 precursor also known as the Gag polyprotein is important for the organization of viral proteins and RNA into new virions. Upon cleavage the p24 protein forms the core of the virus providing structural integrity. These proteins interact with other viral components during the assembly and maturation processes ensuring efficient viral particle production and release.
Pathways
The Gag polyprotein and its resulting products such as p24 are critical in the HIV-1 life cycle pathways. They contribute to the formation and budding of viral particles from the host cell membrane. In these pathways they interact with the host cell machinery and other viral proteins like Pol which is responsible for reverse transcription and integration. The interplay between these proteins ensures the successful replication and spread of the virus.
HIV1 proteins p55 and p24 have a direct connection to acquired immunodeficiency syndrome (AIDS) caused by HIV-1 infection. The viral load often measured through p24 levels correlates with disease progression and immune system deterioration. The proteins also relate to disorders involving immune system dysfunction due to their involvement in virus assembly and release. They connect with the host's immune proteins like CD4 which the virus uses as a receptor to enter cells leading to immune system weakening.