Abcam, ab308182, Anti-SNAP91 antibody [HL1657]

Size: 100µL
Rabbit Recombinant Monoclonal Snap91 antibody. Carrier free. Suitable for WB, IHC-P and reacts with Rat, Human, Mouse, Cat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1657,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human, Mouse, Cat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AP180 also known as AP3K is a protein with a mass of about 90 kDa that has essential roles in endocytosis and synaptic vesicle recycling. This protein is expressed in the nervous system particularly in the brain. AP180 regulates clathrin-coated vesicle formation by facilitating the assembly of clathrin coats on vesicles. It interacts with clathrin through a specific domain ensuring that vesicles have the necessary structural components to capture and transport neurotransmitters effectively.
Biological function summary
AP180 ensures proper functioning of synaptic transmission by assisting in the regulation of vesicle trafficking. It forms part of a complex required for vesicle budding from the plasma membrane. AP180's ability to bind clathrin with high specificity and affinity makes it indispensable for maintaining the vesicular system's integrity. The protein participates in assembling clathrin lattices which are fundamental for creating adequately-sized synaptic vesicles critical for efficient neurotransmission.
Pathways
AP180 integrates into the synaptic vesicle cycle and endocytic pathway thereby influencing neural communication. In the context of the synaptic vesicle cycle AP180 works closely with proteins like synaptotagmin and synaptophysin for efficient neurotransmitter release and recycling. It also interacts within the endocytic pathway to regulate membrane retrieval an action important in synapses where neurotransmitter availability depends on this fast recycling process. These interactions highlight AP180's central role in maintaining synaptic function and stability.
AP180 connects to cognitive disorders and neurodegenerative diseases. Its malfunction might contribute to cognitive impairments as observed in Alzheimer's disease models due to its pivotal role in synaptic vesicle recycling and transmission. Moreover abnormalities in AP180 could influence Parkinson's disease pathways given its interaction with other synaptic proteins such as alpha-synuclein which is implicated in the disease. Therefore AP180 represents a significant target for understanding synaptic dysregulation in these neurodegenerative conditions.