Abcam, ab308336, Anti-Hepatitis D virus Large delta protein antibody [HL1051]

Size: 100µL
Rabbit Recombinant Monoclonal Hepatitis D Virus antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Transfected cell line - Hepatitis D virus samples. Immunogen corresponding to Synthetic Peptide within Hepatitis delta virus (ISOLATE D380) Large delta antigen.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1051,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Hepatitis D virus,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Hepatitis delta virus (ISOLATE D380) Large delta antigen. The exact immunogen used to generate this antibody is proprietary information.P29996

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatitis D Virus (HDV) also known as delta virus is a small circular RNA virus. It is unique among viruses because it requires the presence of Hepatitis B Virus (HBV) for its replication and infection cycle. The delta protein encoded by the HDV RNA genome has an important role in its replication. The delta protein typically has a mass of approximately 24 kDa and is expressed specifically in the liver cells of infected individuals. Due to its dependence on HBV HDV is classified within the family of Deltaviridae.
Biological function summary
The delta protein interacts with host cellular machinery to facilitate HDV replication. It is part of a ribonucleoprotein complex that consists of the viral RNA and the delta protein itself. The complex enables the replication of the viral genome and packaging of the mature virus. The HDV RNA acts as both a template for replication and a ribozyme allowing it to self-cleave and process into the mature genomic RNA. The delta protein in its large form is essential for encapsidation with the HBV surface antigens completing the assembly of infectious virus particles.
Pathways
Hepatitis D virus follows a unique co-infective pathway relying heavily on the HBV lifecycle. The interaction between the HDV delta protein and HBV surface antigens particularly the large HBV surface antigen plays an important role in the assembly and secretion of new virions. HDV actively manipulates the host cellular pathways to facilitate its replication and requires the host's RNA polymerase II for synthesizing its RNA genome. The HBV-associated pathogenesis further accentuates liver damage caused by co-infection.
HDV infection significantly contributes to severe liver diseases including fulminant hepatitis and liver cirrhosis and it increases the risk of hepatocellular carcinoma in affected patients. The combined infection of HDV and HBV leads to a more aggressive disease course and the presence of HBV proteins especially the surface antigen is necessary for HDV propagation. Research into hepatitis D antibodies targets these viral proteins to develop novel therapeutic strategies and prevent liver disease progression.