Abcam, ab308371, Anti-SARS CoV 2 COVID 19 Envelope antibody [HL1443]

Size: 100µL
Rabbit Recombinant Monoclonal VEMP antibody. Carrier free. Suitable for ICC/IF, WB and reacts with Transfected cell line - SARS-CoV-2 samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within SARS-CoV-2 E.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:HL1443,
Isotype:IgG,
Carrier free:Yes,
Reacts with:SARS-CoV-2,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within SARS-CoV-2 E. The exact immunogen used to generate this antibody is proprietary information.P0DTC4

Product details:
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The SARS-CoV envelope protein also known as E protein is a small membrane protein with a mass of approximately 9.6 kDa. It is a structural component of the SARS coronavirus and integrates into the viral envelope. This protein expresses primarily in the membranes of infected host cells contributing to virion assembly budding and release. The E protein acts as an ion channel and facilitates virus-to-host cell interaction which is critical during the coronavirus life cycle.
Biological function summary
The E protein functions within virus replication and pathogenesis. It forms part of the viral assembly complex interacting with the membrane (M) protein and nucleocapsid (N) protein during virion maturation. The E protein impacts the host cell’s cellular pathways by altering membrane permeability and modulating host cell stress responses. Additionally its ion channel activity contributes to virus-host cell interactions and is believed to play a role in immune response evasion.
Pathways
The E protein participates in the coronavirus replication and assembly process. It is involved in the virion assembly pathway and interacts with other viral proteins like the M and N proteins to facilitate this process. The E protein's role in the modification of the host cell’s Golgi apparatus assists in viral budding and release an essential part of the coronavirus replication cycle that is important for efficient viral propagation.
The E protein has significance in the pathogenesis of severe acute respiratory syndrome (SARS) and its role in coronavirus infections. Its interaction with other viral proteins like the structural M protein contributes to the inflammatory responses seen in SARS-CoV infections. Additionally due to its ion channel activity the E protein could influence respiratory complications by affecting cellular stress and apoptosis pathways associated with SARS-CoV related diseases.