Abcam, ab308516, Anti-HOXA10 antibody [EPR27317-76]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal HOXA10 antibody. Suitable for ChIP-seq, WB, Dot, ICC/IF, Flow Cyt (Intra), IP and reacts with Human, Recombinant fragment - Human, Synthetic peptide - Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27317-76,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, Flow Cyt (Intra), WB, ChIP-seq, Dot, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The homeobox protein A10 (HOXA10) also known as HOX1H is a transcription factor with important functions in gene regulation. HOXA10 has a molecular mass of approximately 38 kDa. It is part of the homeobox gene family and is expressed predominantly in the developing uterus and the hematopoietic system. This expression pattern indicates its role in development and differentiation processes particularly in these tissues where it controls several developmental genes.
Biological function summary
HOXA10 is involved in developmental regulation of gene expression. It acts as a transcription factor and binds to DNA sequences to regulate expression of target genes necessary for proper morphogenesis. HOXA10 often operates within multi-protein complexes cooperating with other proteins to exert its function efficiently. By orchestrating gene transcription HOXA10 contributes to the formation and development of certain organs and tissues.
Pathways
The regulatory role of HOXA10 is evident in the Wnt and ERK signaling pathways. These pathways involve critical development and morphogenesis functions where HOXA10 acts as a transcriptional regulator. In the Wnt pathway HOXA10 interacts with proteins like β-catenin to influence cell fate decisions. In the ERK pathway it influences cellular proliferation and differentiation processes integrating signals that contribute to organ development.
HOXA10 has been associated with infertility and certain forms of leukemia. Mutations or altered expression of HOXA10 can disrupt normal uterine development leading to infertility issues. Additionally aberrations in HOXA10 expression are linked with leukemia where its interaction with proteins like MEIS1 alters cell cycle regulation and contributes to oncogenic transformation. Understanding these disease associations offers potential therapeutic targets for managing these conditions.