Abcam, ab309187, Human OSMR ELISA Kit - Extracellular

Size: 1 x 96Tests
Human OSMR ELISA Kit - Extracellular is a Sandwich (quantitative) ELISA for the measurement of Human OSMR - Extracellular in Human in Biofluids, Cell Culture Media samples.
Key facts
Detection method:Colorimetric,
Sample types:Serum, EDTA Plasma, Cell culture supernatant,
Reacts with:Human,
Assay type:Sandwich (quantitative),
Sensitivity:= 15.56 pg/mL,
Range:43.75 - 2800 pg/mL,
Assay time:1h 30m,
Assay Platform:Pre-coated microplate (12 x 8 well strips)

Product details:
Human OSMR - Extracellular SimpleStep ELISA® kit is a single-wash 90 min sandwich ELISA designed for the quantitative measurement of OSMR - Extracellular protein in human serum, EDTA plasma and cell culture supernatant. Quantitate Human OSMR - Extracellular with 15.56 pg/ml sensitivity.
SimpleStep ELISA® technology employs capture antibodies conjugated to an affinity tag that is recognized by the monoclonal antibody used to coat our SimpleStep ELISA® plates. This approach to sandwich ELISA allows the formation of the antibody-analyte sandwich complex in a single step, significantly reducing assay time. See the SimpleStep ELISA® protocol summary in the image section for further details. Our SimpleStep ELISA® technology provides several benefits:
-Single-wash protocol reduces assay time to 90 minutes or less
-High sensitivity, specificity and reproducibility from superior antibodies
-Fully validated in biological samples
-96-wells plate breakable into 12 x 8 wells strips
A 384-well SimpleStep ELISA® microplate (
ab203359
) is available to use as an alternative to the 96-well microplate provided with SimpleStep ELISA® kits.

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Oncostatin M receptor commonly known as OSMR is an important membrane-bound receptor involved in numerous cellular processes. It is part of the type I cytokine receptor family and often forms heterodimers with gp130 to mediate its functions. OSMR has a mass of approximately 115 kDa and predominantly expresses in tissues such as skin lung liver and the nervous system. Alternative names for OSMR include Oncostatin-M-specific receptor beta subunit and IL-31 receptor beta.
Biological function summary
OSMR plays a significant role in regulating inflammatory responses and cell growth. It is part of a receptor complex that upon activation triggers intracellular signaling cascades driven by cytokines like Oncostatin M and IL-31. OSMR involvement influences processes including acute phase responses hematopoiesis and nerve cell differentiation. Its action helps mediate the communication between cells to respond to external inflammatory signals effectively.
Pathways
OSMR is actively involved in the JAK/STAT signaling pathway and the MAPK pathway. In JAK/STAT OSMR collaborates with related proteins like gp130 and participates in promoting transcriptional activity of specific genes in response to cytokine signaling. OSMR’s engagement in the MAPK pathway influences cellular responses such as proliferation differentiation and apoptosis linking it with proteins such as MAP Kinases that further proceed this signaling cascade.
OSMR shows a connection with atopic dermatitis and various cancers. Aberrant OSMR signaling can lead to excessive inflammatory responses contributing to skin conditions like atopic dermatitis often involving IL-31 in the pathway. In cancer elevated OSMR expression correlates with tumorigenesis and progression establishing its interaction with oncogenic proteins in the STAT3 pathway which may promote malignant cell behavior. Through these disease interactions OSMR represents a potential therapeutic target worth exploring.