Abcam, ab309510, Anti-FOXK1/MNF antibody [EPR27320-65]

Size: 20µL / 100µL / 1mL
Anti-FOXK1/MNF antibody [EPR27320-65] is a Rabbit Monoclonal antibody that is used in FOXK1/MNF ChIP-seq, Flow Cytometry (Intra), ICC/IF, IHC-P, IP, Western Blot. Suitable for Human, Mouse, Rat samples. FOXK1, also known as myocyte nuclear factor (MNF), is a transcriptional regulator involved in various cellular processes such as glucose metabolism, muscle cell differentiation, and autophagy. It binds to specific DNA sequences to modulate gene expression, playing a key role in cell cycle regulation and metabolic reprogramming
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27320-65,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Mouse, Rat,
Applications:IHC-P, WB, ChIP-seq, ICC/IF, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FOXK1/MNF protein often called Forkhead Box K1 is a transcription factor that regulates gene expression linked to cell proliferation and differentiation. It has the molecular weight of approximately 84 kDa. Expressed in various tissues including muscle and brain FOXK1/MNF plays an essential role in regulating specific gene targets. The protein interacts with DNA via its forkhead domain influencing the transcriptional activity of numerous genes important for cellular functions.
Biological function summary
FOXK1/MNF is involved in the regulation of cell cycle progression and muscle regeneration. It forms part of a transcriptional complex that modulates gene expression to control these processes. In muscle tissue FOXK1/MNF influences the activation of satellite cells which are necessary for muscle repair and growth. This protein’s function in regulating cellular proliferation highlights its significance in tissue development and regeneration.
Pathways
The FOXK1/MNF protein is instrumental in the Wnt signaling and PI3K/AKT pathways. These pathways are significant for controlling cell proliferation differentiation and survival. Within these pathways FOXK1/MNF interacts with proteins such as beta-catenin in the Wnt signaling pathway. Through these interactions it modulates the transcription of genes responsible for various cellular functions further underlining its role in tissue regeneration and cancer development.
FOXK1/MNF links notably with certain cancers and muscular dystrophies. In cancer its overexpression can lead to unchecked cell proliferation and tumor growth interacting closely with proteins like PTEN a known tumor suppressor. In muscular dystrophy FOXK1/MNF may influence the disease progression by affecting the muscle regeneration process a vital element in maintaining muscle integrity. Understanding its expression and regulation can provide insights into the mechanisms driving these diseases and offer targets for potential therapeutic interventions.