Abcam, ab309513, Anti-CD151 antibody [EPR27423-31] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CD151 antibody. Carrier free. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse, Rat samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27423-31,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Rat, Human, Mouse,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CD151 also known as PETA-3 or SFA-1 is a member of the tetraspanin family which are small membrane proteins with molecular mass of about 28 kDa. This protein is commonly expressed on various cells such as epithelial cells endothelial cells and platelets. CD151 is known to interact with integrins especially integrin α3β1 and α6β1 playing significant roles in cell adhesion and migration. It is mostly found in areas where cell-to-cell contact is vital for maintaining tissue integrity and cellular communication.
Biological function summary
CD151 engages in the stabilization of integrin complexes which facilitates signal transduction pathways that influence cellular behaviors like proliferation differentiation and survival. It does not function alone; CD151 is part of a tetraspanin-enriched microdomain (TEM) forming complexes that include proteins such as CD9 CD63 and other integrins. These complexes bring together structural and signaling molecules on the cell membrane creating platforms for efficient signal relay.
Pathways
CD151 plays a role in pathways involving cell adhesion and tissue repair. Notably it is involved in the integrin signaling pathway which is essential for cell-matrix interactions in tissues that require adhesion for repair or restructuring. CD151 interacts with proteins like PI3K and Akt within these pathways which are central to the signaling cascades regulating cellular responses to the extracellular environment.
CD151 participation has been noted in cancer progression and metastasis. It links to the dysregulation observed in integrin functions such as those of integrin α3β1 which directly influences tumor cell invasion and metastasis in cancers like breast and prostate cancer. CD151 also exhibits connections with renal pathologies including Alport syndrome where the lack of functional basement membranes affects kidney function and it interacts with proteins like collagen IV in the disorder's progression.