Abcam, ab313341, Anti-Influenza A virus NS1 protein antibody [EPR28247-51]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NS1 antibody. Suitable for WB, IHC-P, ICC/IF, Flow Cyt (Intra), I-ELISA and reacts with Influenza A, Transfected cell lysate - Influenza A, Transfected cell line - Influenza A, Recombinant fragment - Influenza A samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR28247-51,
Isotype:IgG,
Carrier free:No,
Reacts with:Influenza A,
Applications:I-ELISA, ICC/IF, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Influenza A Nonstructural Protein 1 often referred to as NS1 is an important component of the influenza virus. This protein has an approximate molecular mass of 26 kDa. NS1 is expressed within infected host cells and functions predominantly in the cytoplasm and nucleus. Mechanically NS1 is known for its ability to bind double-stranded RNA effectively modulating host immune responses by interfering with the host's antiviral mechanisms.
Biological function summary
NS1 impacts several critical processes by inhibiting the host cell's immune response. It is not part of a larger protein complex yet it interacts with other cellular factors to suppress the production of interferon an important molecule in antiviral defense. Through its multifunctional activities including binding to cellular proteins and RNA NS1 alters normal host cell processes to benefit viral replication and persistence.
Pathways
NS1 strategically manipulates the host's cellular pathways to thwart the immune response. Two major pathways affected include the interferon signaling pathway where NS1 prevents the activation and transcription of interferon and the apoptosis pathway where it limits cell death aiding in viral replication. NS1 also interacts with proteins like RIG-I which are important in sensing viral RNA and initiating immune responses.
NS1 plays a significant role in the pathogenesis of influenza infections such as seasonal flu and pandemic influenza. Its ability to suppress the host's immune response can exacerbate these conditions leading to increased disease severity. Additionally NS1's interactions with other viral proteins like HA and NA contribute to the virus's overall pathogenicity and adaptation to host defenses. Understanding NS1's functionalities can aid in developing therapeutic strategies and vaccines against influenza-related illnesses.