Abcam, ab313433, Anti-LNX2 antibody [RP23040098]

Size: 100µg
Rabbit Recombinant Multiclonal LNX2 antibody. Suitable for ICC/IF, WB and reacts with Human samples.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040098,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LNX2 also known as Ligand of Numb-protein X 2 is an E3 ubiquitin-protein ligase that plays a central role in controlling protein degradation. The molecular mass of LNX2 is approximately 73 kDa. This protein commonly appears in tissues such as the brain and liver. LNX2 contains several PDZ domains which facilitate protein-protein interactions and it is involved in the ubiquitination pathway marking proteins for degradation.
Biological function summary
LNX2 interacts with other proteins to regulate cellular signaling processes. LNX2 often forms part of a larger protein complex that includes Numb a protein involved in cell fate determination. Through these interactions LNX2 modulates important cellular functions like endocytosis and cell signaling important for maintaining cellular homeostasis. LNX2's role in interacting with several proteins indicates its importance in cellular regulatory networks.
Pathways
LNX2 significantly contributes to the Notch signaling pathway which regulates cell differentiation and proliferation. LNX2 interacts with the Numb protein within this pathway influencing the outcome of signal transduction. Additionally LNX2 has roles within the Wnt signaling pathway another critical pathway in cell fate decisions and embryonic development. These pathways highlight LNX2's involvement in regulating key cellular processes in developmental biology.
LNX2 has associations with cancers particularly in the brain and liver where its expression is prominent. Alterations in LNX2 expression or function may disrupt the balance of cellular signaling pathways and contribute to tumorigenesis. Additionally LNX2 has connections with neurological disorders potentially due to its regulation of Numb and subsequent effects on neurodevelopmental pathways. LNX2's involvement in these diseases underlines its potential as a therapeutic target.