Abcam, ab313441, Anti-Kindlin-1 antibody [RP23040116]

Size: 100µg
Rabbit Recombinant Multiclonal Kindlin-1 antibody. Suitable for ICC/IF, WB and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FERMT1.
Key facts
Host species:Rabbit,
Clonality:Multiclonal,
Clone number:RP23040116,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FERMT1.Q9BQL6

Product details:
What are recombinant multiclonals?
Recombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:
- The sensitivity of polyclonal antibodies by recognising multiple epitopes
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
View our range of
recombinant multiclonal antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Kindlin-1 also known as FERMT1 is a protein that plays an important role in integrin-mediated cellular functions. It has a molecular mass of about 75 kDa and is mainly expressed in epithelial cells particularly in the skin and intestine. The Kindlin-1 protein assists in activating integrins by binding to their tails and facilitating integrin-ligand interactions on the cell surface which are important for cell adhesion and signal transduction.
Biological function summary
Kindlin-1 influences cell adhesion migration and proliferation. It is a component of a complex that includes talin another integrin activator which stabilizes interactions at the cell matrix interface. The Kindlin-integrin interaction impacts actin cytoskeleton remodeling an important step for maintaining the structural integrity and functions of epithelial tissues. The proper functioning of Kindlin-1 in cellular dynamics ensures tissue homeostasis and repair.
Pathways
Kindlin-1 is involved in the integrin signaling pathway and the focal adhesion pathway. Integrin signaling is essential for transmitting mechanical and chemical signals from the extracellular matrix into the cell influencing cellular responses. The cooperation with proteins like talin and paxillin in these pathways highlights Kindlin-1’s role in regulating cell movement and mechanical sensing. These pathways contribute to pathological and physiological processes including wound healing and tissue morphogenesis.
Mutations in the Kindlin-1 gene link to Kindler Syndrome a rare autosomal recessive disorder. This condition affects the skin’s ability to repair itself and causes photosensitivity and skin blistering. Additionally Kindlin-1 is connected to inflammatory bowel disease due to its presence in intestinal epithelial cells. Alterations in Kindlin-1 expression or function can disrupt the balance of integrin-mediated adhesion impacting interactions with other components like collagen and impacting epithelial integrity therefore bearing relevance in the context of these disorders.