Abcam, ab313577, Anti-alpha 1 Adrenergic Receptor antibody [EPR27512-50]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal alpha 1d Adrenergic Receptor antibody. Suitable for IHC-P, WB and reacts with Mouse, Transfected cell line - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR27512-50,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The alpha 1d adrenergic receptor also known as the alpha-1d adrenoceptor is a G-protein-coupled receptor with mass approximately 70 kDa. It plays a critical role in the modulation of physiological responses by binding catecholamines like norepinephrine and epinephrine. Alpha-1d adrenergic receptor is widely expressed in vascular smooth muscle heart liver and central nervous system. This receptor remains an important target for pharmacological research due to its involvement in various physiological processes.
Biological function summary
The alpha-1d adrenergic receptor promotes vasoconstriction and increases blood pressure through the activation of phospholipase C pathway resulting in calcium release from intracellular stores. It functions as part of a receptor complex that interacts with other alpha-1 adrenergic subtypes such as alpha-1a and alpha-1b adrenergic receptors differentiating their roles in tissue-specific actions. These receptor activities affect muscle contraction and influence systemic vascular resistance.
Pathways
This adrenergic receptor is engaged in the adrenergic signaling in cardiomyocytes and vascular smooth muscle contraction pathways. It facilitates communication between the signaling molecules and cellular responses. The alpha-1d adrenergic receptor partners with proteins like Gq/11 protein family which mediates signal transduction leading to its physiological effects. Interaction with other receptors such as beta-adrenergic receptors shapes the overall cardiovascular outcomes by providing a balance between constriction and relaxation.
The alpha-1d adrenergic receptor links to hypertension and benign prostatic hyperplasia where its modulation can influence disease progression and treatment outcomes. In hypertension dysregulation of alpha-1d adrenergic signaling may alter vascular tone and resistance contributing to elevated blood pressure. Connections with proteins such as phospholipase C confirm its involvement in the signaling cascade that affects these conditions. Modulation of this receptor activity offers therapeutic potential for related cardiovascular and urological disorders.