Abcam, ab313612, Anti-LILRB5 antibody [EPR23896-84]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal LILRB5 antibody. Suitable for WB, Flow Cyt (Intra), ICC/IF and reacts with Human, Transfected cell lysate - Human, Transfected cell line - Human samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR23896-84,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LILRB5 protein also known as Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 has an approximate mass of 65 kDa. It belongs to the immunoglobulin superfamily and is primarily found on the surface of several immune cells including monocytes and macrophages. LILRB5 plays a significant role in down-modulating immune responses by interacting with its ligands.
Biological function summary
This protein functions as an inhibitory receptor that modulates immune cell activation and responses. It is not part of a larger protein complex but works individually to regulate anti-inflammatory signaling pathways. Its activity helps maintain immune homeostasis and prevents overactivation of immune responses which can lead to tissue damage.
Pathways
LILRB5 acts within the context of immune response regulation. It is involved in pathways related to immunosuppressive signaling notably the PD-1 receptor pathway. LILRB5 interacts with other immune-regulating proteins like LILRB1 and PD-L1 which coordinate to control immune checkpoint signaling suppressing excessive immune reactions.
LILRB5 has connections to autoimmune diseases and cancer. Its role in suppressing immune responses links it to autoimmune conditions where inappropriate targeting of self-tissues occurs suggesting that its dysregulation may lead to such disorders. Furthermore in cancer tumor cells might exploit LILRB5-mediated pathways to evade immune surveillance. Related proteins like LILRB1 and PD-L1 further complicate these pathways influencing disease progression and therapeutic outcomes.