Abcam, ab313624, Anti-KCNA antibody [EPR26383-85]

Size: 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal Kv1.2 antibody. Suitable for mIHC, WB, IHC-P and reacts with Rat, Mouse, Human, Transfected cell lysate - Mouse, Recombinant fragment - Mouse samples.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26383-85,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:IHC-P, mIHC, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Human species is recommended based on IHC result. We do not guarantee western blot for human.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
KCNA also known as Kv1.1 is a potassium voltage-gated channel. This protein plays an important role in setting the resting membrane potential and in shaping the action potentials in excitable tissues. Kv1.1 has a mass of around 56 kDa and it is mainly expressed in the central nervous system particularly in neurons. The channel belongs to the shaker-related subfamily and helps regulate the flow of K+ ions across the cell membrane contributing to neuronal excitability and signaling.
Biological function summary
Kv1.1 is critical in the regulation of electrical signaling within neurons. It forms part of heterotetrameric complexes with other voltage-gated potassium channels influencing the duration and frequency of action potentials. Its activity directly affects neurotransmission and synaptic plasticity. The proper functioning of Kv1.1 ensures balanced excitatory and inhibitory signals in the brain contributing to normal neuronal circuit operations.
Pathways
The activity of Kv1.1 impacts both the regulation of neurotransmitter release and neuronal excitability pathways. It interacts closely with other ion channels and signaling molecules such as Na+ channels to maintain cellular homeostasis. By modulating the action potential frequency Kv1.1 affects long-term potentiation (LTP) an important pathway associated with learning and memory. Its function integrates into complex signaling networks that involve interactions with proteins like the Nav1.1 sodium channel which influences excitatory signaling in neurons.
Mutations or dysfunctions in Kv1.1 have connections to episodic ataxia type 1 and neuromyotonia. These conditions result from improper ion channel function leading to unregulated neuronal activity. In episodic ataxia type 1 Kv1.1 mutations lead to coordination loss due to altered Purkinje cell activity while neuromyotonia involves hyperexcitability at the motor nerve terminals. Both disorders highlight the critical role of Kv1.1 in maintaining neuronal function and stability often involving other proteins like the KCNA2 and KCNA3 subunits that may also contribute to similar channelopathies.