Abcam, ab313692, Recombinant Mouse TNFRSF11B Protein (Fc)

Size: 10µg / 50µg / 100µg
Recombinant Mouse TNFRSF11B Protein (Fc) is a Rat Full Length protein, in the 22 to 401 aa range, expressed in HEK 293 cells, with >0.95%, <0.005 EU/µg endotoxin level, suitable for Mass Spec, SDS-PAGE, HPLC.
Key facts
Purity:>0.95% HPLC,
Endotoxin level:<0.005 EU/µg,
Expression system:HEK 293 cells,
Tags:Tag free,
Applications:SDS-PAGE, HPLC, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:O08727,
Animal free:Yes,
Carrier free:No,
Species:Rat,
Storage buffer:pH: 7.4Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTF3L1 also known as basic transcription factor 3-like protein 1 is a transcription factor with a mass of approximately 22-25 kDa. Mechanically BTF3L1 acts as part of the preinitiation complex where it plays a role in regulating transcription. It binds to the nascent preinitiation complex and enhances the accuracy of transcription initiation. BTF3L1 is expressed in various tissues but has high expression in the brain liver and testis which suggests a role in specific cellular processes in these organs.
Biological function summary
BTF3L1 is involved in transcription initiation and helps in stabilizing the interaction between RNA polymerase II and promoter DNA. It functions as part of the larger BTF3 complex which is essential in forming the transcription initiation complex at pol II promoters. This complex facilitates the binding and proper assembly of other transcription factors which improves the overall efficiency and fidelity of transcription.
Pathways
BTF3L1 plays a role in the transcription regulation pathway specifically with RNA polymerase II transcription machinery. It is related to important transcription factors like TFIID contributing to the initiation of transcription. It also has connections to the cell cycle control pathway where it ensures that transcription is accurately conducted during cell division. Interaction with these pathways indicates its involvement in key cellular processes that require precise transcription.
BTF3L1 has connections to cancer and neurodegenerative diseases. In cancers abnormal expression levels of BTF3L1 have been linked to tumor progression and metastasis potentially due to its role in transcription regulation. It interacts with proteins such as c-Myc known to be involved in oncogenesis. In neurodegenerative diseases disruptions in BTF3L1 expression might contribute to neuronal dysfunction due to its essential role in maintaining normal transcription processes critical for neuron function.