Abcam, ab313781, Anti-NOR1/TEC antibody [EPR26986-37]

Size: 10µL-TRIAL / 20µL / 100µL / 1mL
Rabbit Recombinant Monoclonal NOR1/TEC antibody. Suitable for WB, IP and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR26986-37,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NOR1 also known as NR4A3 or nuclear receptor subfamily 4 group A member 3 is an orphan nuclear receptor with a molecular mass of about 60 kDa. NOR1 expression occurs widely across various tissues like brain muscle and pancreas suggesting its diverse physiological roles. As a transcription factor NOR1 regulates gene expression by binding to specific DNA sequences. Its activity depends on the cellular context and the presence of specific cofactors or ligands.
Biological function summary
NOR1 functions as an important regulator of gene transcription involved in cellular growth differentiation and metabolism. NOR1 is part of the nuclear receptor superfamily but unlike many nuclear receptors it does not have a defined hormone ligand. The protein often works alone or may associate with other nuclear receptors or transcription factors to modulate target genes. Research indicates its involvement in important cellular processes like the inflammatory response and apoptosis.
Pathways
NOR1 plays a significant role in the regulation of the MAPK signaling pathway and the T-cell receptor signaling pathway. Within these pathways it interacts with other nuclear receptors and transcription factors such as its family members NR4A1 and NR4A2. These interactions influence cell survival proliferation and immune responses. NOR1 can modulate the expression of various genes thereby linking it to complex cellular networking and pathway modulation.
NOR1 shows strong connections to cancer and metabolic disorders. Its dysregulation is implicated in certain cancers such as acute myeloid leukemia likely due to altered gene transcription control. NOR1's role in metabolic disorders comes from its influence on genes governing glucose metabolism and insulin sensitivity. Proteins like NR4A1 and NR4A2 often exhibit related patterns of expression or function in these diseases further emphasizing the intricate relationship between NOR1 and disease pathogenesis.